Readers should be careful about deleting the FontCacheTool. For me, the solution (workaround) has been to u8se Font Finagles, a $7 shareware product thqat nukes font cache files. The fonts aren't corrupt, but something about having lots of fonts corrupts one or more cache file frequently.
I have a lot of fonts and get this frequently, combined with the familiar problem of cascading bogus corrupt font messages. Joelbruner recommends trashing (or at least moving) Office 2004's FontCacheTool to stop problems with optimizing the font menu on startup. If a nation expects to be ignorant and free, in a state of civilization, it expects what never was and never will be. Since in that environment I mostly thought of the universal settings as a good thing, I didn't keep notes on the particulars, but it's definitely something for Office users to be aware of. It was also common, as Rob points out in this case, for the switches to be located in different places. I recall from when I had to live more in Office that this kind of change-in-one-reset-in-all behavior was fairly common.